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I would like to share my opinion concerning Hydrea, I hope it would be useful to someone who still haven't found an effective medication or is not sure about the choice. I have been on this medication (1 capsule a day) since the year 2010. I was diagnosed with Myeloperliferative Disease about 7 years ago and since that time I have tried several medications that were supposed to bring my platelets and hemoglobin levels down. And to be honest some of other cancer meds were more or less effective, but I inevitably had to stop the treatment courses and ask my doctor to switch me to another med because of the side effects I couldn't tolerate. Most awful side effects were unbearable pain in my muscles and bones that would keep me awake for many nights on end. I also had nausea and fatigue that would keep me away from my usual duties. I do have a serious illness but I want to stay active and to live my life the way I am used to. And when medications produce some effect but make me suffer and forget about normal life, then these meds are not for me. With Hydrea everything is quite different. I have side effects but they are not that serious for me to stop treatment. Besides the drug is really good for its purpose. So, while looking for something more effective or better to say while waiting for the pharmacists to create a new med, I am more than ok with Hydrea.

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We focused on the chemical-genetic screens for FK506, CsA, fluconazole, benomyl, hydroxyurea and camptothecin, and we collected genetic interaction data either for the gene encoding the drug target or for functionally related genes whose products function within the pathway affected by the compound.

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EFFECT OF HYDROXYUREA IN SICKLE CELL ANEMIA: A Clinical Trial in Children and Teenagers with Severe Sickle Cell Anemia and Sickle Cell beta-Thalassemia.

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And if both parents have it, they have a one-in-four chance of having a child with full-scale sickle-cell disease.

Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma.

The other mechanism increasing the severity in beta-thalassemia heterozygotes depends on the presence of a mutation in the beta globin gene, which causes an extreme instability of the beta globin chains.

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Multiply transfused patients before 1992, when a screening test for hepatitis C was introduced in blood banks, were at risk for the transmission of hepatitis C virus (HCV).

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Patients known to have antibodies to HIV were excluded from the study, but there is no evidence that hydroxyurea is harmful to such persons.

Unlike some patients with uremia, none of our patients with sickle cell disease had any increase in blood pressure after receiving infusions of erythropoietin.

Health-related quality of life in children with sickle cell disease: child and parent perception.

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Interestingly clopidogrel has been reported to reduce parameters of leukocyte activation and thus its use may be more appropriate in patients with myeloproliferative disorders in whom the thrombophilic state is increasingly attributed to platelet and leukocyte activation and to platelet-leukocyte interactions ().

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For this reason, most insurance plans do not do blanket approval of any and all FDA-approved medications and will often require a staged approval process, where a patient will have to have been unresponsive or have had significant adverse effects to less expensive medications before more expensive treatments are considered.

Controlled trial of hydroxyurea vs placebo in 145 patients with HIV infection on didanosine and stavudine found no excess toxicity with addition of hydroxyurea, no mention of ALT elevations, hepatitis, liver failure or drug fever).

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SN has remained relatively underdiagnosed and understudied despite its onset early on in life: classic biomarkers of renal damage are normal even in the face of existing chronic sickle kidney disease, until extensive renal damage has occurred.

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Much of that progress grew out of focusing on the basics, including developing hydroxyurea, still the only Food and Drug Administration-approved drug that targets sickling.

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